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KONOPLEVA, MARINA
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KONOPLEVA, MARINA
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Academic Article
MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex.
Concept
MAP Kinase Kinase 2
Concept
Mitogen-Activated Protein Kinase Kinases
Concept
MAP Kinase Kinase Kinases
Concept
MAP Kinase Kinase 4
Concept
MAP Kinase Kinase 1
Academic Article
Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells.
Academic Article
MEK blockade converts AML differentiating response to retinoids into extensive apoptosis.
Academic Article
Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia.
Academic Article
Therapeutic potential of MEK inhibition in acute myelogenous leukemia: rationale for "vertical" and "lateral" combination strategies.
Academic Article
Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia.
Academic Article
Leukotriene B4 receptor inhibitor LY293111 induces cell cycle arrest and apoptosis in human anaplastic large-cell lymphoma cells via JNK phosphorylation.
Academic Article
Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells.
Academic Article
Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells.
Academic Article
PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer.
Academic Article
Oral MEK 1/2 Inhibitor Trametinib in Combination With AKT Inhibitor GSK2141795 in Patients With Acute Myeloid Leukemia With RAS Mutations: A Phase II Study.
Academic Article
A Phase II Study of Azacitidine, Venetoclax, and Trametinib in Relapsed or Refractory Acute Myeloid Leukemia Harboring RAS Pathway-Activating Mutations.
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Mitogen Activated Protein Kinase Kinases